Multi-drug Urinalysis Reagent Strips

Explain ：

The Urinalysis Reagent Strips (Urine) are firm plastic strips onto which several separate reagent areas are affixed. The test is for the qualitative and semi-quantitative detection of one or more of the following analytes in urine: Ascorbic acid, Glucose, Bilirubin, Ketone (Acetoacetic acid), Specific Gravity, Blood, pH, Protein, Urobilinogen, Nitrite and Leukocytes.

【PRINCIPLE】

The Rapid Response Drugs of Abuse Test Device detects Drugs of Abuse through visual interpretation of color development on the internal strip. Drug conjugates are immobilized on the test region of the membrane. During testing, the specimen reacts with antibodies conjugated to colored particles and precoated on the sample pad. The mixture then migrates through the membrane by capillary action, and interacts with reagents on the membrane. If there are insufficient drug molecules in the specimen, the antibody-colored particle conjugate will bind to the drug conjugates, forming a colored band at the test region of the membrane. Therefore, a colored band appears in the test region when the urine is negative for the drug. If drug molecules are present in the urine above the cut-off concentration of the test, they compete with the immobilized drug conjugate on the test region for limited antibody binding sites. This will prevent attachment of the antibody-colored particle conjugate to the test region. Therefore, the absence of a colored band at the test region indicates a positive result. The appearance of a colored band at the control region serves as a procedural control, indicating that the proper volume of specimen has been added and membrane wicking has occurred.

Adulteration Test Strips:
Drug adulteration test strips are used to determine if the urine sample has been intentionally manipulated, contaminated or diluted in order to pass a drug screen. A six in one test, it identifies the following: Creatinine, Glutaraldehyde, Nitrite,
Specific Gravity Oxidants( bleach, and Pyridinium Chlorochromate), pH-Testing.
Adulteration Test Strips (Specimen Validity Tests):
When a donor attempts to alter the drug test result by tampering with the urine specimen that is considered to be adulteration.
The use of adulterants can cause false negative results in drug tests by destroying the drugs present in the urine or interfering with the test itself.
There are several methods Drug Abusers have used to try and beat the drug test such as diluting or adding substances to the specimen, flushing their system, etc. Adulteration test strips (Specimen Validity Tests) are a cost effective way to determine if the donor has adulterated their specimen in as little as 1 minute.
Parameters on Adulteration Test Strips (SVT):
* Creatinine – Creatinine is a waste product of creatine, an amino-acid contained in muscle tissue and found in urine. A person may attempt to foil a test by drinking excessive amounts of water or diuretics such as herbal teas to “flush” the system.Creatinine and specific gravity are two ways to check for dilution and flushing. Low creatinine and specific gravity levels may indicate dilute urine. The absence of creatinine (<5 mg/dl) is indicative of a specimen not consistent with human urine.
* Specific Gravity tests for sample dilution. Values outside the normal range of 1.003 to 1.030 may be the result of specimen dilution or adulteration.
* Nitrite – include common commercial adulterants such as Klear or Whizzies. They work by oxidizing the major cannabinoid metabolite THC-COOH. Normal urine should contain no trace of nitrite.
* Glutaraldehyde – Adulterants such as UrinAid and Clear Choice contain glutaraldehyde which may cause false negative screening results by disrupting the enzyme used in some immunoassay tests. Glutaraldehyde is not normally found in urine.
* pH – Normal pH levels should be in the range of 4.0 to 9.0. Values outside of this range may indicate sample tampering.
* Oxidants/PCC – Oxidizing agents such as bleach, hydrogen peroxide and pyridinium chlorochromate (UrineLuck) are commonly used adulterants. Normal human urine should not contain oxidants or PCC.

Available in the following formats:
* Dip strip (packaged 25 per canister)
* Also available in some multi-drug panel and integrated cup formats.